TORCH

Yes, you are obliged to collect consent. Please consult the ICF form

No, MICK-MAGMA does not automatically remove drugs from the list of available drugs based on contraindications entered in the extended “Essential Treatment Information” form. You are responsible for ensuring that the patient does not have contraindications to any of the drugs recommended by MICK-MAGMA

In cases where the MICK-MAGMA analysis determines that the Mtb strain causing TB disease has a “moderate probability of resistance”, it indicates that there the drug may or may not be effective. You can include the drug in the regimen but additional drugs should be included to increase the forgiveness of the regimen

If you have been waiting for several days for feedback, please contact the NCAC and/or PCAC secretary to request that they review your case as soon as possible

When resistance to one of the BPaLM drugs is detected, with a moderate or high probability, the design of an individualized effective regimen is challenging.

A doctor may only see very few DR-TB patients and may therefore lack the required expertise. Some doctors may have the ability to consult a clinical advisory committee or expert in MDR-TB treatment. However, many doctors or other healthcare workers in high burden DR-TB settings may not have ready access to expert consultation. The treatment recommender addresses this need by supplementing expert consultations, giving healthcare workers evidence-based recommendations for the treatment of patients that are unable to receive standard treatment regimens.